Publications

2024

  • Docampo, R. (2024) Advances in the cellular biology, biochemistry and molecular biology of acidocalcisomes. Microbiol. Mol. Biol.Rev. e0004223, in press.

2023

  • Docampo, R. (2023) Praziquantel target validation of a Ca2+ permeable channel in schistosomes. Cell Calcium 110, 102698.
  • Negrão, N., Mantilla, B.S., Baptista, R.P., King-Keller, S., Huang, G, and Docampo, R (2023) An X-domain phosphoinositide phospholipase C (PI-PLC-like) of Trypanosoma brucei has a surface localization and is essential for proliferation. Pathogens 12, 386.
  • Boeynaems, S,, Dorone, Y., Zhuang, Y., Shabardina, V., Huang, G., Marian, A., Kim, A., Sanyal, A., Sen, N.-E., Griffith, D., Docampo, R., Lasker, K., Ruiz-Trillo, I., Auburger, G., Holehouse, A.S., Kabashi, E., Lin, Y., Gitler, A.D. (2023) Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates. Mol. Cell 83, 2020-2034.

2022

  • Docampo, R., and Vercesi, A.E. (2022) Mitochondrial Ca2+ and reactive oxygen species in trypanosomatids. Antiox. Redox Signal. 36 (13-15), 969-983.
  • Pezza, A., Tavernelli, L., Alonso, V., Perdomo, V., Gabarro, R., Prinjha, R., Rodríguez Araya, E., Rioja, I., Docampo, R., Calderón, F., Martin, J., Serra, E. (2022) Essential bromodomain TcBDF2 as a drug target against Chagas disease. ACS Infect. Dis. 8 (5), 1062-1074.
  • Gomaa, F., Beaudoin, D.J., Alzan, H., Girguis, P.R., Docampo, R., and Edgcomb, V.P. (2022) CRISPR/Cas9-induced disruption of Bodo saltans paraflagellar rod-2 gene reveals its importance for cell survival. Environ Microbiol. 24 (7), 3051-3062.
  • Docampo, R., and Huang, G. (2022) New insights into the role of acidocalcisomes in trypanosomatids. J. Eukaryot. Microbiol. 69 (6), e12899.
  • Bertolini, M., and Docampo, R. (2022) MICU1 and MICU2 potentiation of Ca2+ uptake by the mitochondrial Ca2+ uniporter of Trypanosoma cruzi and its inhibition by Mg2+. Cell Calcium 107, 102654.  

2021

  • Lander, N., Chiurillo, M.A., and Docampo, R. (2021) Signaling pathways in environmental sensing in Trypanosoma cruzi. Mol. Microbiol. 115, 819-828.
  • Docampo, R., and Huang, G. (2021) The IP3 receptor and Ca2+ signaling in trypanosomes. Biochim. Biophys. Acta - Mol. Cell Res. 1868, 118947.
  • Mantilla, B.S., do Amaral, L., Jessen, H., and Docampo, R. (2021) The inositol pyrophosphate biosynthetic pathway in Trypanosoma cruzi. ACS Chem. Biol. 16, 283-292.
  • Mantilla, B.S., Kalesh, K., Brown, N.W., Fiedler, D., and Docampo, R. (2021) Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7)-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages. Mol. Microbiol. 115, 986-1004.
  • Ramakrishnan, S. Unger, L.M., Baptista, R.P., Cruz-Bustos, T., and Docampo, R. (2021) Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn2+ in protein glycosylation needed for host cell invasion and intracellular replication. PLoS Path. 17, e1009399.
  • Docampo, R., Vercesi, A.E., Huang, G., Lander, N., Chiurillo, M.A. and Bertolini, M. (2021) Mitochondrial Ca2+ homeostasis in trypanosomes. Int. Rev. Cell Mol. Biol. 362, 261-289.
  • Negreiros, R., Lander, N., Chiurillo, M.A., Vercesi, A.E., and Docampo, R. (2021) Mitochondrial pyruvate carrier subunits are essential for pyruvate-driven respiration, infectivity, and intracellular replication of Trypanosoma cruzi. mBio 12:e00540-21.
  • Ramakrishnan, S., Baptista, R., Asady, B., Huang, G., and Docampo (2021) TbVps41 regulates trafficking of endocytic but not biosynthetic cargo to lysosomes of bloodstream forms of Trypanosoma brucei. FASEB J. 35:e21641.
  • Perez-Castiñeira, J.R., Docampo, R., Ezawa, T., and Serrano, A. (2021) Editorial: pyrophosphates and polyphosphates in plants and microorganisms Front. Plant Sci. 12, 653416.
  • dos Santos, G.R.M., Rezende Leite, A.C., Lander, N., Chiurillo, M.A., Vercesi, A.E., and Docampo, R. (2021) Trypanosoma cruzi Letm1 is involved in mitochondrial Ca2+ transport, and is essential for replication, differentiation, and host cell invasion. FASEB J. 35, e21685.
  • Stasic, A.J., Dykes, E.J., Cordeiro, C.D., Vella, S.A., Fazli, M.S., Quinn, S., Docampo, R., and  Moreno, S.N.J. (2021) Ca2+ entry at the plasma membrane and uptake by acidic stores is regulated by the activity of the V-H+-ATPase in Toxoplasma gondii. Mol. Microbiol. 115, 1054-1068.
  • Chiurillo, M.A., Jensen, B.C., and Docampo, R. (2021) Drug target validation of the protein kinase AEK1, essential for proliferation, host cell invasion, and intracellular replication of the human pathogen Trypanosoma cruzi. Microbiol. Spectrum. 9, e0073821.
  • Docampo, R. and Moreno, S.N. (2021) Calcium signaling in intracellular protist parasites. Curr. Opin. Microbiol. 64, 33-40.
  • Mantilla, B.S., Azevedo, C., Denny, P.W., Saiardi, A., and Docampo, R. (2021) The histidine ammonia lyase of Trypanosoma cruzi is involved in acidocalcisome alkalinization and is essential for survival under starvation stress. mBio 12, e198121-21.

2020

  • Lander, N., Chiurillo, M.A., and Docampo, R. (2020) CRISPR/Cas9 technology applied to the study of proteins involved in calcium signaling in Trypanosoma cruzi. Meth. Mol. Biol. 2116, 177-197.
  • Huang, G., Moreno, S.N.J., and Docampo, R. (2020) Isolation and characterization of acidocalcisomes from trypanosomatids. Meth. Mol. Biol. 2116, 673-688.
  • Docampo, R. (2020) Catching polyphosphorylation in the act. J. Biol. Chem., 295, 1452-1453.
  • Lander, N., Cruz-Bustos, T., and Docampo, R. (2020) A CRISPR/Cas9-riboswitch based method for downregulation of gene expression in Trypanosoma cruzi. Front. Cell. Inf. Microbiol., 10, 68.
  • Huang, G., and Docampo, R. (2020) The mitochondrial calcium uniporter interacts with subunit c of the ATP synthase of trypanosomes and humans. mBio, 11, e00268-20.
  • Mathias, F., Cohen, A., Kabri, Y., Negrão N.W., Crozet, M.D., Docampo, R, Azas, N., and Vanelle, P. (2020) Synthesis and in vitro evaluation of new 5-substituted 6-nitroimidazooxazoles as antikinetoplastid agents. Eur. J. Med. Chem., 191, 112146.
  • Faktorová, D, Nisbet, E.R., Fernández Robledo, J.A., Casacuberta, E., Sudek, L., Allen, A.E., Ares Jr., M., Aresté, C., Balestreri, C., Barbrook, A.C., Beardslee, P., Bender, S., Booth, D.S., Bouget, F.Y., Bowler, C., Breglia, S.A., Brownlee, C., Burger, G, Cerutti, H., Cesaroni, R., Chiurillo, M.A., Clemente, T., Coles, D.B., Collier, J.L., Cooney, E.C., Coyne, K., Docampo, R. et al. (2020) Genetic tool development in marine protists: Emerging model organisms for experimental cell biology. Nat. Meth. 17, 481-494
  • Cipriani, M., Rostán, S., León, I., Li, ZH, Gancheff, J.S., Kemmerling, U., Azar, C.O., Etcheverry, S., Docampo, R., Gambino, D., and Otero, L. (2020) Multi-target heteroleptic palladium bisphosphonate complexes. J. Biol. Inorg. Chem. 25, 509-519.
  • Ning, Y., Frankfater, C., Hsu, F.-F., Soares, R.P., Cardoso, C.A., Nogueira, P.M., Lander, N.M., Docampo, R., and Zhang, K. (2020) Lathosterol oxidase (sterol C-5 desaturase) deletion confers resistance to Amphotericin B and sensitivity to acid stress in Leishmania major. mSphere 5, e00380-20.
  • Chiurillo, M.A., Lander, N., Vercesi, A.E., and Docampo, R. (2020) IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi. Cell Calcium 92, 102284.
  • Bertolini, M., and Docampo, R. (2020) Different sensitivity of control and MICU1- and MICU2-ablated Trypanosoma cruzi mitochondrial calcium uniporter complex to ruthenium-based inhibitors. Int. J. Mol. Sci. 21, 9316.

2019

  • Chao, N., Lorenzo-Ocampo, M.V., Szajnman, S.H., Docampo, R., and Rodriguez, J.B. (2019) Further insights of selenium-containing analogues of WC-9 against Trypanosoma cruzi. Bioorg. Med. Chem. 27, 1350-1361.
  • Lander, N., Chiurillo, M.A., and Docampo, R. (2019) Genome editing by CRISPR/Cas9 in Trypanosoma cruzi. Meth. Mol. Biol. 1955, 61-76.
  • Potapenko, E., Cordeiro, C.D., Huang, G., and Docampo, R. (2019) Pyrophosphate stimulates the phosphate/sodium symporter of Trypanosoma cruzi and Saccharomyces cerevisiae vacuoles. mSphere 4: e00045-19.
  • Bertolini, M.S., Chiurillo, M.A., Lander, N., Vercesi, A., and Docampo, R. (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. mBio 10: e00348-19
  • Cordeiro, C.D., Ahmed, M.A., Windle, B., and Docampo, R. (2019) NUDIX hydrolases with inorganic exo- and endopolyphosphatase activities in the glycosome, cytosol and nucleus of Trypanosoma brucei. Biosci. Rep. 39: BSR20190894.
  • Chiurillo, M.A., Lander, N., Bertolini, M., Vercesi, A.E., and Docampo, R. (2019) Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi. Mol Biol Cell 30, 1676-1690.
  • Potapenko, E., Negrão, Huang, G., and Docampo, R, (2019) The acidocalcisome inositol-1,4,5-trisphosphate receptor of Trypanosoma brucei is stimulated by luminal polyphosphate hydrolysis products. J. Biol. Chem. 294, 10628-10637.

2018

  • Cruz-Bustos, T., Potapenko, E., Storey, M., and Docampo, R. (2018) An intracellular ammonium transporter is necessary for replication, differentiation and resistance to starvation and osmotic stress in Trypanosoma cruzi. mSphere 3: e00377-17.
  • Cruz-Bustos, T., Ramakrishnan, S., Cordeiro, C.D., Ahmed, M.A., and Docampo, R. (2018) A riboswitch-based inducible gene expression system for Trypanosoma brucei. J. Eukaryot. Microbiol. 65, 412-421.
  • Demoro, B., Rostan, S., Moncada, S., Li, Z.-H., Docampo, R., Azar C.O., Maya, J.D., Torres, J., Gambino, D., and Otero, L. (2018) Ibandronate metal complexes: solution behavior and antiparasitic activity. J Biol. Inorg. Chem. 23, 303-312.
  • Lander, N., Chiurillo, M.A., Bertolini, M.S., Docampo, R., and Vercesi, A.E. (2018) The mitochondrial calcium uniporter complex in trypanosomes. Cell Biol. Int. 42, 656-663.
  • Cruz-Bustos, T., Moreno, S.N.J., Docampo, R. (2018) Detection of weakly expressed Trypanosoma cruzi membrane proteins using high-performance probes. J. Eukaryot. Microbiol., 65, 722-728.
  • Ramakrishnan, S. Asady, B., Docampo, R. (2018) Acidocalcisome-mitochondrion membrane contact sites in Trypanosoma brucei. Pathogens 7, 33.
  • Ramakrishnan, S., Docampo, R. (2018) Membrane proteins in trypanosomatids involved in Ca2+ homeostasis and signaling. Genes 9, 304.
  • Huang, G., Docampo, R. (2018) The mitochondrial Ca2+ uniporter complex (MCUC) of Trypanosoma brucei is a hetero-oligomer that contains novel subnits essential for Ca2+ uptake. mBio 9, e1700-18.
  • Negreiros, R.S., Lander, N., Huang, G., Cordeiro, C.D., Smith, S.A., Morrissey, J.H., Docampo, R. (2018) Inorganic polyphosphate ineracts with nucleolar and glycosomal proteins. Mol. Microbiol. 110, 973-994.
  • Lander, N., Chiurillo, M.A., Bertolini, M.S., Storey, M., VercesJ. Biol. Chem.i, A.E., and Docampo, R. (2018) Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation and infectivity of Trypanosoma cruzi. J. Biol. Chem. 293, 17402-17417.
  • Potapenko, E., Cordeiro, C.D., Huang, G., Storey, M., Witwer, C, Dutta, A.J., Jessen, H.J., Starai, V.J., and Docampo, R. (2018) 5-Diphosphoinositol pentakisphosphate (5-IP7) regulates phosphate release from acidocalcisomes and yeast vacuoles. J. Biol. Chem. 293, 19101-19112.

2017

  • Docampo, R., and Moreno, S.N.J. (2017) Biochemistry of Trypanosoma cruzi. In American Trypanosomiasis, 2nd Ed. (Tybairenc, M. and Telleria, J., Eds), Elsevier.
  • Galaka, T, Ferrer Casal, M., Storey, M., Li, C., Cahoa,M.N., Szajnman, S.H., Docampo, R., Moreno, S.N.J., and Rodriguez,J.B. (2017) Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and Apicomplexan parasites. Molecules 22, 82
  • Chiurillo, M.A., Lander, N., Bertolini, M.S., Storey, M., Vercesi, A.E., and Docampo, R. (2017) Different roles of mitochondrial calcium uniporter complex subunits in growth andinfectivity of Trypanosoma cruzi. mBio 8 (2): e00574-17.
  • Cordeiro, C.D., Saiardi, A., and Docampo, R. (2017) The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes. Mol Microbiol. 106: 319-333.
  • Zhuo, Y., Cordeiro C.D., Hekmaytar, S.K., Docampo, R., and Prestegad, J.H. (2017) Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei. J Biol. Chem. 292, 18161-18168.
  • Lander, N., Chiurillo, M.A., Vercesi, A., Docampo, R. (2017) Endogenous C-terminal tagging by CRISPR/Cas9 in Trypanosoma cruzi. Bio-Protoc 7, 10:21769/BioProtoc 2299.
  • Chao, M.N., Storey, M., Li, C., Rodriguez, M.C., Si Salvo, F., Szajnman, S.H., Moreno, S.J., Docampo, R., Rodriguez, J.B. (2017) Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation. Bioorg. Med. Chem. 25, 6435-6449.

2016

  • Lander, N., Cordeiro, C., Huang, G, and Docampo, R. (2016) Polyphosphate and acidocalcisomes. Biochem. Soc. Trans. 44 (1), 1-6.
  • Docampo, R. (2016) The origin and evolution of the acidocalcisome and its interactions with other organelles. Mol. Biochem. Parasitol. 209, 3-9.
  • Docampo, R. and Huang, G. (2016) Acidocalcisomes of eukaryotes. Curr. Opinion Cell Biol. 41, 66-72.
  • Lander, N., Chiurillo, M.A., and Docampo, R. (2016) Genome editing by CRISPR/Cas9: a game change in the genetic manipulation of protists. J. Eukaryot. Microbiol. 63, 679-690.
  • Docampo, R. (2016) Polyphosphate storage and function in acidocalcisomes. In Inorganic Polyphosphates in Eukaryotic Cells. (Kulakovskaya, T., Pavlov, E., Dedkova, E.N. Eds), Springer International Publishing, Switzerland. pp. 35-48.
  • Yang, Y., Ko, T.P., Chen, C.C., Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M.R., Hsu, S.D., O’Dowd, B., Huff, H.C., Huang, C.H., Docampo, R., Oldfield, E., and Guo, R.T. (2016) Structures of trypanosome vacuolar soluble pyrophosphatases: anti-parasitic drug targets. ACS Chem. Biol. 11, 1362-1371.
  • Lander, N., Chiurillo, M.A., Storey, M., Vercesi, A.E., and Docampo, R. (2016) CRISPR-Cas9-mediated C-terminal tagging of Trypanosoma cruzi genes reveals the acidocalcisome localization of the inositol-1,4,5-trisphosphate receptor. J. Biol. Chem. 291, 25505-25515.
  • Chao, M.N., Li, C., Storey, M., Falcone, B.N., Szajnman, S.H., Bonesi, S.M., Docampo, R., Moreno, S.N., and Rodriguez, J.B. (2016) Activity of fluorine-containing analogues of WC-9 and structurally related analogues against two intracellular parasites: Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem 11. 2690-2702.

2015

  • Docampo, R., and Huang, G. (2015) Calcium signaling in trypanosomatid parasites. Cell Calcium 57, 194-202.
  • Veiga-Santos, P., Li, K., Huang, G., Lameira, L., Ulisses de Carvalho, T.M., Galizzi, M., Shang, N., Li, Q., Gonzalez-Pacanowska, D., Hernandez-Rodriguez, V., Benaim, G., Guo, R.T., Urbina, J., Docampo, R., de Souza, W., and Oldfield, E. (2015) SQ109: a new drug lead for Chagas disease. Antimicrob. Agents Chemother 59, 1950-1961.
  • Niyogi, S., and Docampo, R. (2015) A novel role of Rab11 in trafficking GPI-anchored trans-sialidase to the plasma membrane of Trypanosoma cruzi. Small GTPases 6 (1), 8-10.
  • Huang, G., and Docampo, R. (2015) Proteomic analysis of acidocalcisomes of Trypanosoma brucei uncovers their role in phosphate metabolism, cation homeostasis, and calcium signaling. Commun. Integr. Biol. 8 (2), e1017174-1.
  • King-Keller, S., Moore, C.A., Docampo, R., and Moreno, S.N.J. (2015) Ca2+ regulation of Trypanosoma brucei phosphoinositide phospholipase C. Eukaryot. Cell, 14(5), 486-494.
  • Li, K., Wang, Y., Yang, G., Byun, S.Y., Rao, G., Shoen, C., Yang, H., Gulati, A., Crick, D.C., Cynamon, M., Huang, G., Docampo, R., No, J.H., and Oldfield, E. (2015) Oxa, thia, heterocycle and carborane analogues of SQ109: bacterial and protozoal cell growth inhibitors. ACS Infect. Dis. 1, 215-221.
  • Chao, M.N., Matiuzzi, C.E., Storey, M., Li, C., Szajnman, S.H., Docampo, R., Moreno, S.N., and Rodriguez, J.B. (2015) Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem. 10, 1094–1108
  • Niyogi, S., Jimenez, V., Girard-Dias, W., de Souza, W., Miranda, K., and Docampo, R. (2015) Rab32 is essential for maintaining functional acidocalcisomes and for growth and infectivity of Trypanosoma cruzi. J. Cell Sci. 128, 2363-2373.
  • Lander, N., Li, Z.H., Niyogi, S., and Docampo, R. (2015) CRISPR/Cas9-induced disruption of paraflagellar rod proteins 1 and 2 genes in Trypanosoma cruzi reveals their role in flagellar attachment. mBio 6 (4), e1012-15.
  • Jimenez, V., and Docampo, R. (2015) TcPho91 is a contractile vacuole phosphate sodium symporter that regulates phosphate and polyphosphate metabolism in Trypanosoma cruzi. Mol. Microbiol., 97, 911-925.
  • Yang, G., Zhu, W., Wang, Y., Huang, G., Byun, S., Choi, K.L., Huang, Z., Docampo, R., Oldfield, E., and No, J.H. (2015) In vitro and in vivo activity of multi-target inhibitors against Trypanosoma brucei. ACS Infect. Dis. 1, 388-398.

2014

  • Ferrer-Casal, M, Li, C., Galizzi, M., Storz, C.A., Szajnman, S., Docampo, R., Moreno, S.N.J., and Rodriguez, J.B. (2014) New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase. Bioorg. Med. Chem. 22, 398-405.
  • Ulrich, P.N., Lander, N., Kurup, S., Reiss, L., Brewer, Soares Medeiros, L Miranda, K., and Docampo, R. (2014) The acidocalcisome vacuolar transporter chaperone 4 catalyzes the synthesis of polyphosphate in insect-stages of Trypanosoma brucei and T. cruzi. J. Eukaryot. Microbiol. 61, 155-165.
  • Porcel, B.M., Denoeud, F., Opperdoes, F., Noel, B., Madoui, M-A., Hammarton, T.C., Field, M.C., Da Silva, C., Couloux, A., Poulain, J., Katinka, M., Jabbani, K., Aury, J.M., Campbell, D.A., Cintron, R., Dickens, N.J., Docampo, R., Sturm, N.R., Koumandu, V.L., Fabre, S., Flegontov, P., Lukeš, J., Michaeli, S., Mottram, J., Szöör, B., Zilberstein, D., Bringaud, F., Wincker, P., and Dollet, M. (2014) The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genetics 10 (2): e1004007.
  • Shang N., Li, Q., Ko, T.-P., Chan, H.-C., Li, J., Zheng, Y., Huang, C.-H., Ren, F., Chen, C.-C., Zhu, Z., Galizzi, M., Li, Z.-H., Rodriguez-Poveda, C.A., Gonzalez-Pocanowska, D., Veiga-Santos, P., Ulisses de Carvalho, T.M., De Souza, W., Urbina, J.A., Wang, A.H.-J., Docampo, R., Li, K., Liu, Y.-L., Odfield, E., and Guo, R.-T. (2014) Squalene synthase as a target for Chagas disease therapeutics. PLoS Pathog. 10 (5): e1004114.
  • Niyogi, S., Mucci, J., Campetella, O., and Docampo, R. (2014) Rab11 regulates trafficking of trans-sialidase to the plasma membrane through the contractile vacuole complex of Trypanosoma cruzi. PLoS Pathog. 10 (6): e1004224.
  • Docampo, R., Moreno, S.N.J., and Plattner, H. (2014) Intracellular calcium channels in protozoa. Eur. J. Pharmacol. 739, 4-18.
  • Docampo, R., Vercesi, A.E., and Huang, G. (2014) Mitochondrial calcium transport in trypanosomes. Mol. Biochem. Parasitol. 196, 108-116.
  • Docampo, R. (2014) Polyphosphate: a target for thrombosis attenuation. Blood, 124, 3177-3178.
  • Huang, G., Ulrich, P.N., Storey, M., Johnson, D., Tischer, J., Tovar, J.A., Moreno, S.N., Orlando, R. and Docampo, R. (2014) Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells. PLoS Path. 10 (12): e1004555.

2013

  • Docampo, R, (2013) Letter from the Editor: Redesign of the articles that now have a more modern look. J. Eukaryot. Microbiol. 60, 1.
  • Recher, M., Barboza, A.P., Li, Z.-H., Galizzi, M., Ferrer-Casal, M., Szajnman, S.H., Docampo, R., Moreno, S.N.J., and Rodriguez, J.B. (2013) Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. Eur. J. Med. Chem. 60, 431-440.
  • Huang, G., Bartlett, P.J., Thomas, A.P., Moreno, S.N.J., and Docampo, R. (2013) Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity. Proc. Natl. Acad. Sci. U.S.A.110, 1887-1892.
  • Tobin, A., and Docampo, R. (2013) Meeting Reports: Signalling in Protist Parasites. The Biochemist, February, p. 64.
  • Moreno, S.N.J., and Docampo, R. (2013) Polyphosphate and its diverse functions in host cells and pathogens. PLoS Pathog. 9(5):e1003230
  • Docampo, R., Jimenez, V., Lander, N., Li, Z.H., Niyogi, S. (2013) New insights into roles of acidocalcisomes and contractile vacuole complex in osmoregulation in protists. Int. Rev. Cell Mol. Biol. 305, 69-113.
  • Galizzi, M., Bustamante, J., Fang, J., Miranda, K., Soares Medeiros, L., Tarleton R., and Docampo, R. (2013) Evidence for a role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence. Mol. Microbiol. 90, 699-715.
  • Elicio, P., Chao, M.N., Galizzi, M., Li, C., Szajnman, S.H., Docampo, R., Moreno, S.N.J., and Rodriguez, J.B. (2013) Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. Eur. J. Med. Chem. 69C, 480-489.
  • Lander, N., Ulrich, P.N., and Docampo, R. (2013) Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection. J. Biol. Chem. 288, 34205-34216.
  • Huang, G., Vercesi, A.E., and Docampo, R. (2013) Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter. Nat. Commun. 4, 2865.
  • Docampo, R., and Moreno, S.N.J. (2013) Calcium in malaria parasites. In M. Hommel & P.G. Kremsner (Eds) Encyclopedia of Malaria, Springer, pp. 1-6.

2012

  • Docampo, R., and Lukes, J. (2012) Trypanosomes and the solution of a 50-year mitochondrial calcium mystery. Trends Parasitol. 28, 31-37.
  • Szajnman, S., Rosso, V., Malayil, L., Smith, A., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2012) 1-(fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase. Org. Biomol. Chem.  10, 1424-1433.
  • Demoro B, Caruso F, Rossi M, Benítez D, González M, Cerecetto H, Galizzi M, Malayil L, Docampo R, Faccio R, Mombrú AW, Gambino D, Otero L. (2012) Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. Dalton Trans. 41, 6468-6476.
  • Long TE, Lu X, Galizzi M, Docampo R, Gut J, Rosenthal PJ. (2012) Phosphonium lipocations as antiparasitic agents. Bioorg. Med. Chem. 22, 2976-2979.
  • Li ZH, De Gaudenzi JG, Alvarez VE, Mendiondo N, Wang H, Kissinger JC, Frasch AC, Docampo R. (2012) A 43-Nucleotide U-rich element in 3'-Untranslated region of large number of Trypanosoma cruzi transcripts is important for mRNA abundance in intracellular amastigotes. J. Biol. Chem. 287, 19058-19069.
  • Jimenez V, Docampo R. (2012) Molecular and Electrophysiological characterization of a novel cation channel of Trypanosoma cruzi. PLoS Path. 8, e1002750.
  • Moreno-Sanchez, D., Hernandez-Ruiz, L., Ruiz, F.A., and Docampo, R. (2012) Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J. Biol. Chem.,287, 28435-28444.
  • Aripirala S, Szajnman SH, Jakoncic J, Rodriguez JB, Docampo R, Gabelli SB, Amzel LM. (2012) Design, synthesis, calorimetry and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. J. Med. Chem. 55, 6445-6454.

2011

  • Li ZH, Alvarez VE, De Gaudenzi JG, Sant'anna C, Frasch AC, Cazzulo JJ, Docampo R. (2011) Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation and global gene expression changes in Trypanosoma cruzi. J. Biol. Chem. 286, 43959-43971
  • Huang, G., Fang, J., Sant'anna, C., Li, Z., Wellems, D. L., Rohloff, P., and Docampo R. (2011) Adaptor protein-3 (AP-3) complex mediates the biogenesis of acidocalcisomes and is essential for growth and virulence of Trypanosoma brucei. J. Biol. Chem. 286, 36619-36630.
  • Ramos I, Gomes F, Koeller CM, Saito K, Heise N, Masuda H, Docampo R, de Souza W, Machado EA, Miranda K. (2011) Acidocalcisomes as calcium- and polyphosphate-storage compartments during embryogenesis of the insect Rhodnius prolixus Stahl. PLoS One 6, e27276.
  • Docampo, R. (2011) Molecular parasitology in the 21st century. Essays Biochem. 51, 1-13.
  • Shively, J, Cannon, G.C., Heinhorst, S., Bryant, D.A., DasSarma, S., Bazilinski, D., Preiss, J., Steinbüchel, A. Docampo, R., Dahl, C., (2011) Bacterial and archaeal inclusions. In Encyclopedia of Life Sciences (eLS). John  Wiley & Sons, Ltd:Chichester, pp. 1-14.
  • Soares Medeiros, L. C., Gomes, F., Maciel, L. R., Seabra, S. H., Docampo, R., Moreno, S. N. J., Plattner, H., Hentschel, J., Kawazoe, U., Barrabin, H., De Souza, W., Damatta, R. A., and Miranda, K. (2011) Volutin granules of Eimeria parasites are acidic compartments and have physiological and structural characteristics similar to acidocalcisomes. J. Eukaryot. Microbiol. 58, 416-423.
  • Docampo, R., Jimenez, V., King-Keller, S., and Moreno, S. N. J. (2011) The role of acidocalcisomes in the stress response of Trypanosoma cruzi. Adv. Parasitol. 75, 307-324.
  • Docampo, R., and Moreno, S. N. J. (2011) Acidocalcisomes. Cell Calcium 50, 113-119
  • Rosso, V.S., Szajnman, S.H., Malayil, L., Galizzi, M., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2011) Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg. Med. Chem. 19, 2211-2217.
  • Lederkremer, R.M., Agusti, R., and Docampo, R. (2011) Inositolphosphoceramide metabolism in Trypanosoma cruzi. A comparison with other trypanosomatids. J. Euk. Microbiol. 58, 79-87.
  • Ulrich, P.N. Jimenez, V., Park, M.,Martins, V., Atwood III, J.,Moles, K., Collins, D., Rohloff, P., Tarleton, R., Moreno, S.N.J., Orlando, R., and Docampo, R. (2011) Identification of contractile vacuole proteins in Trypanosoma cruzi. Plos One 6, e18013.
  • Schoijet, A.C., Miranda, K., Soares Medeiros, L.C. de Souza, W., Flawia, M.M., Torres, H.N.,Pignataro, O., Docampo, R., and Alonso, G.D. (2011) Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi. Mol. Microbiol. 79, 50-62.

2010

  • Martins V.P., Okura M., Maric D., Engman D.M., Vieira M., Docampo R., Moreno S.N. (2010) Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J. Biol Chem., 285 (40) 30906-30917.
  • Demoro, B., Caruso, F., Rossi, M., Benítez, D., Gonzalez, M., Cerecetto, H., Parajón-Costa, B., Castiglioni, J., Galizzi, M., Docampo, R., Otero, L., and Gambino, D. (2010) Risedronate metal complexes potentially active against Chagas disease. J. Inorg. Biochem. 104, 1252-1258.
  • Martins, V.P., Galizzi, M., Docampo, R., and Moreno, S.N.J. (2010) Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis. Inf. Immun., 78 (10) 4206-4212.
  • King-Keller, S., Li, M., Smith, A., Zheng, S., Kaur, G., Yang, X., Wang, B., and Docampo, R. (2010) Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas disease. Antimicrob. Agents Chemother., 54 (9) 3738-3745.
  • De Jesus, T.C.L., Tonelli, R.R., Nardelli, S.C., Augusto, L.S., Motta, M.C.M., Girard-Dias, W., Kiranda, K., Ulrich, P., Jimenez, V., Barquilla, A., Navarro, M., Docampo, R., and Schenkman, S. (2010) Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma cruzi. J. Biol. Chem., 285, 24131-24140.
  • Singh, A.P., Zhang, Y., No, J.-H., Docampo, R., Nussenzweig, V., and Oldfield, E. (2010) Lipophilic bisphosphonates are potent inhibitors if Plasmodium liver-stage growth. Antimicrob. Agents Chemother. 54 (7), 2987-2993.
  • Ramos, I., Miranda, K., Pace, D.A., Verbist, K.C., Lin, F.-Y., Zhang, Y., Oldfield, E., Machado, E.A., de Souza, W., and Docampo, R. (2010) Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP. Biochem. J. 429,485-495.
  • Docampo, R., and Moreno, S.N.J. (2010) Biochemistry of Trypanosoma cruzi. In “American Trypanosomiasis” (Tybairenc, M. and Telleria, J., Eds), Elsevier, pp. 365-392.
  • Ramos, I.B., Miranda, K., Ulrich, P., Ingram, P., LeFurgey, A., Machado, E.A., de Souza, W., and Docampo, R. (2010) Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk. Biol. Cell 102, 421-434.
  • Patel, S., and Docampo, R. (2010) Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling. Trends Cell Biol. 20(5), 277-286.
  • Ulrich, P., Cintrón, R., and Docampo, R. (2010) Calcium homeostasis and acidocalcisomes in Trypanosoma cruzi. In Structures and Organelles in Pathogenic Protists. Microbiol. Monograps. Springer-Verlag, Berlin Heidelbe, 17, 299-318 .
  • Docampo, R., Ulrich, P., and Moreno, S.N.J. (2010) Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes. Phil. Trans. R. Soc. B365, 775-784.
  • Lander, N., Bernal, C., Diez, N., Añez, N., Docampo, R., and Ramirez, J.J. (2010) Localization and developmental regulation of a dispersed gene family-1 (DGF-1) protein in Trypanosoma cruzi. Inf. Immun. 78, 231-240.

2009

  • Patel, S., and Docampo, R. (2009) In with the TRP channels: intracellular functions for TRPM1 and TRPM2. Sci Signal. 2 (95) pe69.
  • Donald, B., Cannon, G., Dahl, C., Docampo, R., Fuerst, J., Heinhorst, S., Maupin-Furlow, J., Pfeifer, F., Preiss, J., Schüler, D., Steinbüchel, A., and Shively, J. (2009) Intracellular structures of Prokaryotes: Inclusions, compartments and assemblages. In: The Encyclopedia of Microbiology, 3rd Edition. Schaechter, M., Ed. Elsevier, p. 404-424.
  • Motta, L.S., Ramos, I.B., Gomes, F.M., de Souza, W., Champagne, D.E, Santiago, M.F., Docampo, R., Miranda, K., and Machado, E.A. (2009) Proton-pyrophosphatase and polyphosphate in acidocalcisome-like vesicles from oocytes and eggs of Periplaneta Americana. Insect Biochem. Mol. Biol. 39, 198-206.
  • Mezencev, R., Galizzi, M., Kutschy, P., and Docampo, R. (2009) Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro. Exp. Parasitol. 122, 66-69.
  • Moreno, S.N.J., and Docampo, R. (2009) The role of acidocalcisomes in parasitic protists. J. Eukaryot. Microbiol. 56, 208-213.

2008

  • Salto, L., Kuhlenschmidt, T, Kuhlenschmidt, M, and Docampo, R. (2008) Phospholipid and glycolipid composition of acidocalcisomes of Trypanosoma cruzi. Mol. Biochem. Parasitol., 158:120-130.
  • Rohloff, P. and Docampo, R. (2008) A contractile vacuole complex is involved in osmoregulation in Trypanosoma cruzi. Exp. Parasitol. 118, 17-24.
  • Docampo, R. (2008) Special section on novel organelles in parasitic protozoa. Exp. Parasitol. 118, 1.
  • Docampo, R., and Moreno, S.N. (2008) The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites. Curr. Pharm. Design,14, 882-888.
  • Szajnman, S.H., García Liñares, G.G., Li, Z-H., Jang, C., Galizzi, M., Bontempi, E., Ferella, M., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2008) Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg. Med. Chem.,16, 3283-3290.
  • Ferella, M., Nilsson, D., Darban, J., Rodrigues, C.O., Bontempi, E.J., Docampo, R., Andersson, B. (2008) Proteomics in Trypanosoma cruzi - Localization of novel proteins to various organelles. Proteomics, 8, 2735-2749.
  • Ferella, M., Li, Z.H., Andersson, B., and Docampo, R. (2008) Farnesyl diphosphate synthases localizes to the cytosol of Trypanosoma cruzi and T. brucei. Exp. Parasitol., 119, 308-312.
  • Schoijet, A. Miranda, K., Girard-Dias, W., de Souza, W., Flawia, M.M., Torres, H.N., Docampo, R., and Alonso, G. (2008) A Trypanosoma cruzi phosphatidylinositol-3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis. J. Biol. Chem. 283, 31541-31550.

2007

  • Fang, J., Rohloff, P., Miranda, K., and Docampo, R. (2007) Ablation of a small transmembrane protein of Trypanosoma brucei (TbVTC1) involved in the synthesis of polyphosphate alters acidocalcisome biogenesis and function, and leads to a cytokinesis defect. Biochem. J. 407, 161-170.
  • Fang, J., Ruiz, F.A., Docampo, M., Luo, S., Rodrigues, J.C., Motta, L.S., Rohloff, P., and Docampo, R. (2007) Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation. J. Biol. Chem. 282, 32501-32510.
  • Linares GG, Gismondi S, Codesido NO, Moreno SN, Docampo R, Rodriguez JB. Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5068-5071.

2006

  • Ravaschino, E., Docampo, R., and Rodriguez, J.B. (2006) Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis. J. Med. Chem. 49, 426-435.
  • Gabelli, S. B., McLellan, J. S., Montalvetti, A., Oldfield, E., Docampo, R., and Amzel, L. M. (2006) Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins 62, 80-88.
  • Smith, S.A., Mutch, N.J., Baskar, D., Rohloff, P., Docampo, R., and Morrissey, J.H. (2006) Polyphosphate modulates blood coagulation and fibrinolysis. Proc. Natl. Acad. Sci. U.S.A., 103, 903-908.
  • Luo, S., Fang, J., and Docampo, R. (2006) Molecular characterization of Trypanosoma brucei P-type H+-ATPases. J. Biol. Chem. 281, 21963-21973.
  • Rohloff, P., and Docampo, R. (2006) Ammonium production during hypo-osmotic stress leads to alkalinization of acidocalcisomes and cytosolic acidification in Trypanosoma cruzi. Mol. Biochem. Parasitol. 150, 249-255.
  • Ferella, M., Montalvetti, A., Rohloff, P., Miranda, K., Fang, J., Reina, S., Kawamaki, M., Búa, J., Nilsson, D., Pravia, C., Katzin, A., Cassera, M.B., Aslund, L., Andersson, B., Docampo, R., and Bontempi, E.J. (2006) A solanesyl-diphosphate synthase localizes I glycosomes of Trypanosoma cruzi. J. Biol. Chem. 281, 39339-39348.
  • Shively, J.M., Cannon, G.C., Heinhorst, S., Bryant, D.A., DasSarma, S., Bazylinski, D., Preiss, J., Steinbüchel, A., Docampo, R., and Dahl, C. (2006) Bacterial Inclusions. In: Encyclopedia of Life Sciences. John Wiley & Sons, pp 1-11.
  • Docampo, R. (2006) Acidocalcisomes and polyphosphate granules. In: Microbiology Monographs. Springer-Verlag Berlin Heidelberg, pp. 53-70.

2005

  • Marshesini N, Vieira, M. Moreno, S.N.J., Docampo, R. A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte (2005). J. Biol. Chem.  280: 36841-7.
  • Miranda, K., Vercesi, A.E., Catisti, R., de Souza, W., Rodrigues, C.O., and Docampo, R. (2005) P-type proton ATPases are involved in intracellular calcium and proton uptake in the plant parasite Phytomonas francai. J. Eukar. Microbiol. 52, 55-60.
  • Docampo, R., de Souza, W., Miranda, K., Rohloff, R., and Moreno, S.N.J. (2005) Acidocalcisomes –conserved from bacteria to man. Nat. Rev. Microbiol. 3:251-261.
  • Okura M, Fang J, Salto ML, Singer RS, Docampo R, Moreno S.N.J. (2005) A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi. J. Biol. Chem. 280:16235-43.
  • Zhang, K., Hsu, F.-F., Scott, D. A., Docampo, R., Turk, J., and Beverley, S. M. (2005) Leishmania salvage and remodeling of host sphingolipids in amastigote survival and acidocalcisome biogenesis. Mol. Microbiol. 55, 1566-1578.
  • Cuevas, I. C., Rohloff, P., Sanchez, D. O. and Docampo, R. (2005) Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi. Euk. Cell 4, 1550-11561.
  • Kotsikorou, E., Song, Y., Chan, J., Faelens, S., Tovian, Z., Broderick, E., Bakalara, N., Docampo, R., and Oldfield, E. (2005) Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble pyrophosphatase. J. Med. Chem. 48, 6128-6139.
  • Vieira, M., Rohloff, P., Luo, S., Cunha-e-Silva, N., de Souza, W., and Docampo, R. (2005) Role for a P-type H+-ATPase in the acidification of the endocytic pathway of Trypanosoma cruzi. Biochem. J. 392, 467-474.
  • Szajnman, S. H., Ravaschino, E. L., Docampo, R., and Rodriguez, J. B. (2005) Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase. Bioorg. Med. Chem. Lett. 15, 4685-4690.

2004

  • Uyemura, S.A., Luo, S., Vieira, M., Moreno, S.N.J. and Docampo, R. Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii mitochondria in situ (2004) J. Biol. Chem.  279(1):385-93.
  • Lemercier, G., Espiau, B., Ruiz, F.A., Vieira, M., Luo, S., Baltz, T., Docampo, R., and Bakalara, N. (2004) A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice. J. Biol. Chem. 279, 3420-3425.
  • Luo, S., Rohloff, P., Cox, J., Uyemura, S. A., and Docampo, R. (2004) Trypanosoma brucei plasma membrane-type Ca2+-ATPase 1 (TbPMC1) and 2 (TbPMC2) genes encode functional Ca2+-ATPases localized to the acidocalcisomes and plasma membrane, and essential for Ca2+ homeostasis and growth. J. Biol. Chem. 279, 14427-14439.
  • Miranda, K., Docampo, R., Grillo, O., Franzen, A., Attias, M., Vercesi, A., Plattner, H., Hentschel, J., and de Souza, W. (2004) Dynamics of polymorphism of acidocalcisomes in Leishmania parasites. Histochem. Cell Biol. 121, 407-418
  • Montalvetti, A., Rohloff, P., and Docampo, R. (2004) A functional aquaporin co-localizes with the vacuolar proton pyrophosphatase to acidocalcisomes and the contractile vacuole complex of Trypanosoma cruzi. J. Biol. Chem. 279, 38673-38682.
  • Mao, J., Gao, Y.-G., Odeh, S., Robinson, H., Montalvetti, A., Docampo, R., and Oldfield, E. (2004) Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei. Acta Crystallographica Section D 60, 1863-1866.
  • Ruiz, F. A., Lea, C. R., Oldfield, E., and Docampo, R. (2004) Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J. Biol. Chem. 279, 44250-44257.
  • Seufferheld, M., Lea, C., Vieira, M., Oldfield, E., and Docampo, R. (2004) The H+-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes. J. Biol. Chem. 279, 51193-51202.
  • Rohloff, P., Montalvetti, A., and Docampo, R. (2004) Acidocalcisomes and the contractile vacuole are involved in osmoregulation in Trypanosoma cruzi. J. Biol. Chem. 279, 52270-52281.
  • Miranda, K., Docampo, R., Grillo, O., and de Souza, W. (2004) Acidocalcisomes of trypanosomatids have species-specific elemental composition. Protist 155, 395-405.
  • Ruiz, F.A., Luo, S., Moreno, S.N.J., and Docampo, R. (2004) Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum. Microsc. Microanal.10(5);117(pt 24):5739-48.
  • Miranda, K., Rodrigues, C.O., Hentchel, J., Vercesi, A., Plattner, H., de Souza, W., and Docampo, R. (2004) Acidocalcisomes of Phytomonas françai possess distinct morphological characteristics and contain iron. Micro. Microanal. 10, 647-655.
  • Docampo, R. (2004) Introduction: A special issue on cellular biology of protozoan parasites. Microsc. Microanal. 10, 511-512.
  • Docampo, R. (2004) Conference summary: New and re-emerging infectious diseases. Emerging Infect. Dis. 10, 1891.
  • Docampo, R., and Moreno, S. N. J. (2004) Wide distribution and function of the H+-pyrophosphatase in prokaryotic and eukaryotic organelles. In; Recent Advances in Inorganic Pyrophosphate Research. Edited by S. A. White, University of Birmingham, pp. 81-85.

2003

  • Salto, M. L., Bertello, L. E. Vieira, M.C.F., Docampo, R., Moreno, S.N.J., Lederkremer, R.M. (2003). Formation and remodeling of inositolphosphoceramide during the differentiation of trypomastigote into amastigote forms of Trypanosoma cruzi. Eukaryotic Cell 2, 756-768.
  • Docampo, R., and Moreno, S.N.J. (2003) Current chemotherapy of human African trypanosomiasis. Parasitol. Res., 90 Supp 1:S10-3.
  • Seufferheld, M., Vieira, M.C.F., Ruiz, F.A., Rodrigues, C.O., Moreno, S.N.J., and Docampo, R. (2003) Identification in bacteria of organelles similar to acidocalcisomes of unicellular eukaryotes. J. Biol. Chem. 278, 29971 – 29978. Hurtley, S.M. (2003) How different are we? Editor's Choice section. Science 300, 2005; Knight, J. (2003) Discovery changes view of bacteria, Nature, 423, 909; Westphall, S.P. (2003) Rewrite the textbooks. New Scientist, 28 June, 22; Whitehouse, D. (2003) Ancient organism challenges cell evolution. BBC News 20 June (http://news.bbc.co.uk/1/hi/sci/tech/3003946.stm)
  • Moreno, S.N.J., and Docampo, R. (2003) Calcium regulation in protozoan parasites. Curr. Opinion Microbiol. 6, 359-364.
  • Moreno, S.N.J., and Docampo, R. (2003) Ca2+ signaling in the invasion of mammalian cells by Trypanosoma cruzi. In: "Molecular Mechanisms of Chagas' Disease Pathogenesis". Edited by J. M. Kelly, Eurekah,. Chapter 5, pp. 73-83.
  • Rohloff, P., Rodrigues, C.O., and Docampo, R. (2003) Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium. Mol. Biochem. Parasitol. 126, 219-230.
  • Montalvetti, A., Fernandez, A., Sanders, J.M., Ghosh, S., Van Brussel, E., Oldfield, E., and Docampo, R. (2003) Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies. J. Biol. Chem. 278, 1075-1083.
  • Urbina, J.A., Concepcion, J.J., Montalvetti, A., Rodriguez, J.B., and Docampo, R. (2003) Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. Antimicrob. Agents Chemother. 47, 2047-2050.
  • Conte, I., Labriola, C., Cazzulo, J.J., Docampo, R., and Parodi, A.J. (2003) The interplay between folding facilitating mechanisms in Trypanosoma cruzi endoplasmic reticulum. Mol. Biol. Cell 14, 3529-3540.
  • Szajnman, S.H., Montalvetti, A., Wang, Y., Docampo, R., and Rodriguez, J.B. (2003) Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. Bioorg. Med. Chem. Lett. 13, 3231-3235.
  • Ravaschino, E.L., Docampo, R., and Rodriguez, J.B. (2003) Synthesis and biological evaluation of glutathione-like tripeptides against Trypanosoma cruzi. Arkivoc 10, 298-313.
  • Garzoni, L.R., Caldera, A., Meirelles, M.N., de Castro, S.L., Docampo, R., Meints, G.A., Oldfield, E., Urbina, J.A. (2003) Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi. Int. J. Antimicrob. Agents 23, 273-285.
  • Garzoni, L.R., Waghabi, M.C., Baptista, M.M., de Castro, S.L., Meirelles, M.N., Britto, C.C., Docampo, R., Oldfield, E., and Urbina, J.A. (2003) Antiparasitic activity of risedronate in a murine model of acute Chagas' disease. Int. J. Antimicrob. Agents 23, 286-290.
  • Urbina, J.A., and Docampo, R. (2003) Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol. 19, 495-501.
  • Docampo, R. (2003) Chemotherapeutic Targets in Parasites. J. Eukar. Microbiol. 50, 144.
  • Docampo, R. (2003) New and re-emerging Infectious diseases. Emerging Infect. Dis. 9, 1030-1033.

2002

  • Salto, M.L., Furuya, T., Moreno, S.N.J., Docampo, R. and Lederkremer, R.M. (2002) The phosphatidylinositol-phospholipase C from Trypanosoma cruzi is active on inositolphosphoceramide. Mol. Biochem. Parasitol. 119, 131-133.
  • Yardley, V., Khan, A.A., Martin, M.B., Slifer, T.R., Araujo, F.G., Moreno, S.N.J., Docampo, R., Croft, S.L. and Oldfield, E. (2002) In vivo activity of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob. Agents Chemother. 46(3):929-31.
  • Moreno, B., Rodrigues, C.O., Bailey, B.N., Urbina, J.A., Moreno, S.N.J., Docampo, R., and Oldfield, E. (2002) Magic-angle spinning 31P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible. FEBS Lett. 523, 207-212.
  • Marchesini, N. and Docampo, R. (2002) A plasma membrane P-type H+-ATPase regulates intracellular pH in Leishmania mexicana amazonensis. Mol. Biochem. Parasitol. 119, 225-236.
  • Rodriguez, N.M., Docampo, R., Lu, H.-G., and Scott, D.A. (2002) Overexpression of the Leishmania amazonensis Ca2+-ATPase gene lmaa1 enhances virulence. Cell. Microbiol. 4, 117-126.
  • Marchesini, N., Ruiz, F.A., Vieira, M., and Docampo, R. (2002) Acidocalcisomes are linked to the contractile vacuole of Dictyostelium discoideum. J. Biol. Chem. 277, 8146-8153.
  • Martinez, R., Wang, Y., Benaim, G., Benchimol, M., de Souza, W., Scott, D.A., and Docampo, R. (2002) A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of Trypanosoma cruzi. Mol. Biochem. Parasitol. 120, 205-213.
  • Van der Heyden, N., and Docampo, R. (2002) Proton and sodium pumps regulate the plasma membrane potential of different stages of Trypanosoma cruzi. Mol. Biochem. Parasitol. 120, 127-139.
  • Rodriguez, N., Bailey, B.N., Martin, M.B., Oldfield, E., Urbina, J.A., and Docampo, R. (2002) Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate. J. Infect. Dis. 186, 138-140.
  • Elhalem, E., Bailey, B.N., Docampo, R., Ujváry, I., Szajnman, S.H., and Rodriguez, J.B. (2002) Design, synthesis and biological evaluation of aryloxyethyl thiocianate derivatives against Trypanosoma cruzi. J. Med. Chem. 45, 3984-3999.
  • Lemercier, G., Dutoya, S., Luo, S., Ruiz, F.A., Rodrigues, C.O., Baltz, T., Docampo, R., and Bakalara, N. (2002) A vacuolar-type H+ pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and bloodstream forms of Trypanosoma brucei. J. Biol. Chem. 277, 37369-37376.
  • Van der Heyden, N., and Docampo, R. (2002) Significant differences between procyclic and bloodstream forms of Trypanosoma brucei in the maintenance of their   plasma membrane potential. J. Eukaryotic Microbiol. 49, 407-413.
  • Luo, S., Scott, D.A., and Docampo, R. (2002) Trypanosoma cruzi H+-ATPase 1 (TcHA1) and 2 (TcHA2) complement yeast mutants defective in H+ pumps and encode plasma membrane P-type H+-ATPases with different enzymatic properties in Trypanosoma cruzi. J. Biol. Chem. 277, 44497-44506.
  • Rodrigues, C.O., Ruiz, F.A., Vieira, M., Hill, J.E., and Docampo, R. (2002) An acidocalcisomal exopolyphosphatase from Leishmania major with higher affinity for short-term polyphosphate. J. Biol. Chem. 277, 50899-50906.
  • Docampo, R. (2002) Fifth Annual Conference on New and Re-Emerging Infectious Diseases. Emerging Infect. Dis. 8, 1008-1010.
  • Docampo, R. (2002) New and Re-Emerging Infectious Diseases. Trends in Parasitol. 18, 334-336.
  • Docampo, R., and Moreno, S.N.J. (2002) Signaling in Trypanosoma cruzi. In "World Class Parasites", vol. IV. Edited by K. M. Kyle and M. Miles., Series Ed.: J.R. Seed and S. Black, Kluwer Academic Publishers, pp. 37-44.

2001

  • Martin, M.B., Grimley, J.S., Lewis, J.C., Heath, H.T. III, Bailey, B.N., Kendrick, H., Yardley, V., Caldera, A., Lira, R., Urbina, J.A., Moreno, S.N.J., Docampo, R., Croft, S.L., and Oldfield, E. (2001). Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy J. Med. Chem. 44, 909-916.
  • Docampo, R., and Moreno, S.N.J. (2001) The acidocalcisome. Mol. Biochem, Parasitol. 33, 151-159.
  • Moreno, B., Bailey, B.N., Luo, S. Martin, M.B., Kuhlenschmidt, M., Moreno, S.N.J., Docampo, R., and Oldfield, E. (2001) 31P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth. Biochem. Biophys. Res. Commun. 284, 632-637
  • Szajnman, S.H., Bailey B. N., Docampo, R. and Rodriguez. J. B. (2001) Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 11, 789-792.
  • Ruiz, F.A., Rodrigues, C.O., and Docampo, R. (2001) Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi. J. Biol. Chem. 276, 26114-26121.
  • Rodrigues, C.O., Catisti, R., Uyemura, S.A., Vercesi, A.E., Lira, R., Rodriguez, C., Urbina, J.A., and Docampo, R. (2001) The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization. J. Eukar. Microbiol. 48, 588-594.
  • Furuya, T., Okura, M., Ruiz, F.A., Scott, D.A. and Docampo, R. (2001) TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi. J. Biol. Chem. 276, 32447-32445.
  • Montalvetti, A., Bailey, B.N., Martin, M.B, Severin, G.W., Oldfield, E., and Docampo, R. (2001) Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J. Biol. Chem. 276, 33930-33937.
  • Ruiz, F.A., Marchesini, N., Seufferheld, M., Govindjee, and Docampo, R. (2001) The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton pumping pyrophosphatase and are similar to acidocalcisomes. J. Biol. Chem. 276, 46196-46203.
  • Docampo, R. and Moreno, S.N.J. (2001) The acidocalcisomal H+-translocating pyrophosphatase of trypanosomatids and apicomplexan parasites. In "New Trends in Inorganic Pyrophosphatase Research", pp. 123-126. Edited by A. Serrano. Sevilla, Universidad de Sevilla, Spain.
  • Docampo, R. (2001) Recent developments in the chemotherapy of Chagas’ disease. Current Pharmaceutical Design 7, 1157-1164.
  • Docampo, R., and Moreno, S.N.J. (2001) Bisphosphonates as potential antiparasitic agents against trypanosomatids and apicomplexan parasites. Curr. Drug Targets-Infectious Disorders, 7, 125-133.
  • Docampo, R. (2001) Atlas of Medical Helminthology and Protozoology. Trends Parasitol. 17, 553.
  • Docampo, R. (2001) Third annual conference on new and re-emerging infectious diseases: in honor of Norman Dion Levine. Acta Trop. 78, 87-88.

2000

  • Furuya, T., Kashuba, C., Docampo, R., and Moreno, S.N.J. (2000) A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation. J. Biol. Chem. 275, 6428-6438.
  • Marchesini, N., Luo, S., Rodrigues, C.O., Moreno, S.N.J., and Docampo, R. (2000) Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites. Biochem. J. 347, 243-253.
  • Uyemura, S.A., Luo, S., Moreno, S.N.J., and Docampo, R. (2000) Oxidative phosphorylation, Ca2+ transport, and fatty acid-induced uncoupling in malaria parasites mitochondria. J. Biol. Chem. 275, 9709-9715.
  • Rodriguez, J.B., Docampo, R., and Gros, E.G. (2000) Sulfur-containing derivatives structurally related to Fenoxycarb are potent growth inhibitors against the intracellular form of Trypanosoma cruzi. Int. J. Antimicrob. Agents 13, 215-218.
  • VanderHeyden, N., and Docampo, R. (2000) Intracellular pH in mammalian stages of Trypanosoma cruzi is K+-dependent and regulated by H+-ATPases. Mol. Biochem. Parasitol. 105, 237-251.
  • Catisti, R., Uyemura, S.A., Docampo, R., and Vercesi, A.E. (2000) Calcium mobilization by arachidonic acid in trypanosomatids. Mol. Biochem. Parasitol., 105, 261-271.
  • Vanderheyden, N., Wong, J., and Docampo, R. (2000) A pyruvate-proton symport and an H+-ATPase regulate intracellular pH of Trypanosoma brucei bloodstream forms. Biochem. J. 346, 53-62.
  • Miranda, K., Benchimol, M., Docampo, R., and de Souza, W. (2000) The fine structure of acidocalcisomes in Trypanosoma cruzi. Parasitol. Res. 86, 373-384.
  • VanderHeyden, N., McLaughlin, G.L., and Docampo, R. (2000) Regulation of the plasma membrane potential in Pneumocystis carinii. FEMS Microbiol. Lett., 183, 327-330.
  • Szajnman, S.H., Yan, W., Bailey, B.N., Docampo, R., Elhalem, E., Rodriguez, J.B., and Gros, E.G. (2000) Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation. J. Med. Chem. 43, 1826-1840.
  • Vercesi, A.E., Rodrigues, C.O., Catisti, R., and Docampo, R. (2000) Presence of a Na+/H+ exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial agents. FEBS Lett. 473, 203-206.
  • Scott, D.A., and Docampo, R. (2000) Characterization of isolated acidocalcisomes of Trypanosoma cruzi. J. Biol. Chem. 275, 24215-24221.
  • Moreno, B., Urbina, J.A., Oldfield, E., Bailey, B.N., Rodrigues, C.O., and Docampo, R. (2000) 31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major: Evidence for high levels of condensed inorganic phosphates. J. Biol. Chem. 275, 28356-28362.
  • Hill, J., Scott, D.A., Luo, S., and Docampo, R. (2000) Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi. Biochem. J. 351, 281-288.
  • Docampo, R. (2000) Infectious diseases: in dedication to Norman D. Levine. Parasitol. Today 16, 316-317.

1999

  • Urbina, J.A., Vierkotter, S., Moreno, B., Oldfield, E., Moreno, S.N.J., Bailey, B.N., Scott, D.A., and Docampo R. (1999) Inorganic pyrophosphate is the most abundant high energy phosphate compound in trypanosomatid and apicomplexan parasites. J. Biol. Chem. 274, 33609-33615.
  • Rodrigues, C.O., Scott, D.A., and Docampo, R. (1999) Presence of a vacuolar H+-pyrophosphatase in promastigotes of Leishmania donovani and its localization to a different compartment from the vacuolar H+-ATPase. Biochem. J. 340, 759-766.
  • Turrens, J.F., Newton, C.L., Zhong, L., Hernandez, F.R., Whitfield, J., and Docampo, R. (1999) Mercaptopyridine-N-oxide, a NADH-fumarate reductase inhibitor, blocks Trypanosoma cruzi growth in culture and in infected myoblasts. FEMS Microbiol. Lett. 175, 217-222.
  • Rodrigues, C.O., Scott, D.A., and Docampo, R. (1999) Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes. Mol. Cell. Biol. 19, 7712-7723.
  • Luo, S., Marchesini, N., Moreno, S.N.J., and Docampo, R. (1999) A plant-like vacuolar H+-pyrophosphatase in Plasmodium falciparum. FEBS Lett. 460, 217-220.
  • Docampo, R., and Moreno, S.N.J. (1999) Acidocalcisomes, a novel calcium storage compartment in trypanosomatids and apicomplexan parasites. Parasitol. Today 15 (11): 443-448.

1998

  • Benchimol, M., de Souza, W., VanderHeyden, N., Zhong, L., Lu, H.G., Moreno S.N.J., and Docampo, R. (1998). Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi. Biochem J. 332, 695-702.
  • Lu, H.-G., Zhong, L., de Souza, W., Benchimol, M., Moreno, S.N.J., and Docampo, R. (1998) Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi. Mol. Cell. Biol. 18(4), 2309-2323.
  • Zhong, L., Lu, H.-G., Moreno, S.N.J., and Docampo, R. (1998) Tyrosine phosphate hydrolysis of host proteins by Trypanosoma cruzi is linked to cell invasion. FEMS Microbiol. Lett. 161, 15-20.
  • Furuya, T., Zhong, L., Meyer-Fernandes, J.R., Lu, H.-G., Moreno, S.N.J., and Docampo, R. (1998) Ecto-protein tyrosine phosphatase activity in Trypanosoma cruzi infective stages. Mol. Biochem. Parasitol. 92, 339-347.
  • Scott, D.A., de Souza, W., Benchimol, M., Zhong, L., Lu, H.-G., Moreno, S.N.J., and Docampo, R. (1998) Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisome of Trypanosoma cruzi. J. Biol. Chem. 273, 22151-22158.
  • Scott, D.A., and Docampo, R. (1998) Two types of H+-ATPase are involved in the acidification of internal compartments in Trypanosoma cruzi. Biochem. J. 331, 583-586.
  • Cinque, G.M., Szajnman, S.H., Zhong, L., Docampo, R., Schvartzapel, A.J., Rodriguez, J.B., and Gros, E.G. (1998) Structure-acitivity relationship of new growth inhibitors of Trypanosoma cruzi. J. Med. Chem.  41, 1540-1554.
  • Scott, D.A., Docampo, R., and Benchimol, M. (1998) Analysis of the uptake of the fluorescent marker 2’,7’-bis-(2-carboxyethyl-5(and-6)-carboxyfluorescein (BCECF) by gydrogenosomes in Trichomonas vaginalis. Eur. J. Cell Biol. 76, 139-145.
  • Rodriguez, J.B., Zhong, L., Docampo, R., and Gross, E.G. (1998) Growth inhibitory effect of juvenile hormone analogues on epimastigotes of Trypanosoma cruzi. BioMed Chem. Lett. 8, 3257-3260.

1997

  • Lu, H.G., Zhong, L., Chang. K.P., and Docampo, R. (1997) Intracellular Ca2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonensis. J. Biol. Chem. 272, 9646-9473.
  • Urbina, J.A., Visbal, G., Contreras, L.M., McLaughlin, G. and Docampo, R. (1997) Inhibitors of D24(25) sterol methyl transferease block sterol synthesis and cell proliferation in Pneumocystis carinii. Antimicrob. Agents Chemother. 41, 1428-1432.
  • Schvartzapel, A.J., Zhong, L., Docampo,.R., Rodriguez, J.B., and Gros, E.G. (1997) Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes). J. Med. Chem. 40, 2314-2322.
  • Scott, D.A., Docampo, R., Dvorak, J.A., Shi, S., and Leapman, R.D. (1997) In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi. J. Biol. Chem. 272, 28020-28029.
  • Vercesi, A.E., Grijalba, M., and Docampo, R. (1997) Inhibition of Ca2+ release from Trypanosoma brucei acidocalcisomes by 3,5-dibutyl-4-hydroxytoluene (BHT): role of the Na+/H+ exchanger. Biochem. J. 328, 479-482.
  • Docampo, R., and Schmuñis, G.A. (1997) Sterol biosynthesis inhibitors as potential chemotherapeutic agents against Chagas' disease. Parasitol. Today 13, 129-130.

1996

  • Moreno, S.N.J. (1996) Pentamidine is an uncoupler of oxidative phosphorylation in rat liver mitochondria. Arch. Biochem. Biophys. 326 (1), 15-20.
  • Vercesi, A.E., and Docampo, R. (1996) Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei. Biochem. J. 315, 265-270.
  • Docampo, R., VanderHeyden, N., Shaw, M.M., Durant, P.J., Bartlett, M.S., Smith, J.W., and McLaughlin, G.L. (1996) An H+-ATPase regulates cytoplasmic pH in Pneumocystis carinii trophozoites. Biochem. J. 316, 681-684.
  • Suju, M., Davila, M., Poleo, G., Docampo, R., and Benaim, G. (1996) Phosphatidylethanol stimulates the plasma-membrane calcium pump from human erythrocytes. Biochem. J. 317, 933-938.
  • VanderHeyden, N., Benaim, G., and Docampo, R. (1996) The role of a H+-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes. Biochem. J. 318, 103-109.
  • Turrens, J.F., Watts, B., Zhong, L., and Docampo, R. (1996) Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives. Mol. Biochem. Parasitol. 82, 125-129.
  • Rodriguez, J.B., Zhong, L., Docampo, R., and Gros, E.G. (1996) Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite. Bioorganic & Medicinal Chemistry Letters 6: 2783-2786.
  • Docampo, R. (1996) Calcium metabolism and cell function. Parasitol. Today 12, 61-65.
  • Docampo R. and Moreno, S.N.J. (1996) The role of calcium in the process of cell invasion by intracellular parasites. Parasitol.Today 12 (2) 61-66.

1995

  • Benaim, G., Moreno, S.N.J., Hutchinson,G. Cervino,V., Hermoso, T., Romero, P.J. Ruiz, F., de Souza, W. and Docampo, R. (1995) Characterization of the plasma membrane calcium pump from Trypanosoma cruzi. Biochem J. 306,299-303.
  • Hoffmann, M.E., Jang, J., Moreno S.N.J., and Docampo, R. (1995) Inhibition of protein synthesis and amino acid transport by crystal violet in Trypanosoma cruzi. J. Eukariot. Microbiol 42 (3), 293-297.
  • Docampo,R., Scott, D.A., Vercesi, A.E. and Moreno, S.N.J. (1995) Intracellular calcium storage in acidocalcisomes of Trypanosoma cruzi. Biochem J. 310 (3), 1005-1012.
  • Scott, D.A., Moreno, S.N.J., and Docampo R. (1995) Calcium storage in Trypanosoma brucei: The influence of cytoplasmic pH and importance of vacuolar acidity. Biochem J.  310 (3), 789-794.
  • Docampo, R. (1995) Antioxidant Mechanisms. In "Biochemistry and Molecular Biology of Parasites ". pp. 147-160. Edited by J.J. Marr and M. Müller. New York, Academic Press, New York.

1994

  • Moreno, S. N. J., Carnieri, E.G.S., and Docampo, R (1994) Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet. Mol. Biochem. Parasitol. 67: 313-320.
  • Moreno, S.N.J., Silva, J., Vercesi, A.E., and Docampo, R. (1994) Cytosolic free calcium elevation in Trypanosoma cruzi  is required for cell invasion. J Exp. Med. 180, 1535-1540.
  • Vercesi, A.E., Moreno, S.N.J., and Docampo, R. (1994) Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei. Biochem. J.  304, 227-233.

1993

  • Docampo, R., Gadelha, F.R., Moreno, S.N.J., Benaim, G., Hoffmann, M.E., and Vercesi, A.E. (1993) Disruption of Ca2+ homoestasis in Trypanosoma cruzi by crystal violet. J. Euk. Microbiol. 40, 311-316.
  • Vercesi, A.E., Moreno, S.N.J., Bernardes, C.F., Meinicke, A.R., Fernandes, E.C., and Docampo, R. (1993) Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. J. Biol. Chem. 268, 8564-8568.
  • Docampo, R., Moreno, S.N.J., and Vercesi, A.E. (1993) Effect of thapsigargin on calcium homeostasis in Trypanosoma cruzi trypomastigotes and epimastigotes. Mol. Biochem. Parasitol.  59, 305-315
  • Carnieri, E.G.S., Moreno, S.N.J., and Docampo, R. (1993) Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages. Mol. Biochem. Parasitol. 61, 79-86.
  • Benaim, G., Lopez-Estraño, C., Docampo, R., and Moreno, S.N.J. (1993) A calmodulin-stimulated Ca2+-pump in plasma membrane vesicles from Trypanosoma brucei. Selective inhibition by pentamidine. Biochem J. 296, 759-763.
  • Vercesi, A.E., Hoffmann, M.E., Bernardes, C.F., and Docampo, R. (1993) ATP and Ca2+ homeostasis in Trypanosoma cruzi. Brazilian J. Med. Biol. Res. 26, 355-363.
  • Docampo, R. (1993) Calcium homeostasis in Trypanosoma cruzi. Biol. Res. 26, 189-196.

1992

  • Moreno, S.N.J., Docampo, R. and Vercesi, A.E. (1992) Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release. J. Biol. Chem. 267, 6020-6026.
  • Moreno, S.N.J., Vercesi, A.E., Pignataro, O.P., and Docampo, R. (1992) Calcium homeostasis in Trypanosoma cruzi amastigotes. Presence of inositol phosphates and absence of an inositol 1,4,5-trisphosphate-sensitive Ca2+ pool. Mol. Biochem. Parasitol. 52, 251-262.
  • Vercesi, A.E., Docampo, R., and Moreno, S.N.J. (1992) Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria. Mol. Biochem. Parasitol. 56, 251-258.
  • Vercesi, A.E., and Docampo, R. (1992) Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effect of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem. J. 284, 463-467.
  • Gadelha, F.R., Hanna, P.M., Mason, R.P., and Docampo, R. (1992) Evidence for free radical formation during horseradish peroxidase-catalyzed N-demethylation of crystal violet. Chemico-Biol. Interact. 85, 35-48.
  • Docampo, R. (1992) Participation of ferredoxin in the reduction of nitroimidazoles by Tritrichomonas foetus hydrogenosomes. An. Asoc. Quim. Argent. 80, 27-34.

1991

  • Docampo, R., and Pignataro, O.P. (1991) The inositol phosphate/diacylglycerol signalling pathway in Trypanosoma cruzi. Biochem. J. 275, 407-411.
  • Vercesi, A.E., Hoffmann, M.E., Bernardes, C.F., and Docampo, R. (1991) Regulation of intracellular calcium homeostasis in Trypanosoma cruzi. Effects of calmidazolium and trifluoperazine. Cell Calcium 12, 361-369.
  • Vercesi, A.E., Bernardes, C.F., Hoffmann, M.E., Gadelha, F.R., and Docampo, R. (1991) Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. J. Biol. Chem. 266, 14431-14434.
  • Benaim, G., Losada, S., Gadelha, F.R., and Docampo, R. (1991) A calmodulin-activated (Ca2+-Mg2+)-ATPase is involved in Ca2+ transport by plasma membrane vesicles from Trypanosoma cruzi. Biochem. J. 280, 715-720.
  • Docampo, R., and Moreno, S.N.J. (1991) The metabolism and mode of action of gentian violet.  Drug. Met. Rev. 22, 1-27, 161-178.
  • Docampo, R. Gadelha, F. and Moreno, S.N.J. (1991) Metabolism and Mode of Anti-Trypanosoma cruzi action of gentian violet.. In Molecular and Immunological Aspects of Parasitism pg. 95-104. Editor C.C. Wang. Washington D.C., American Association for the Advancement of Science.

1990 and before

  • Docampo, R., and Moreno, S.N.J. (1990) The metabolism and mode of action of gentian violet.. Drug. Met. Rev. 22, 1-27, 161-178.
  • Docampo, R. (1990) Male Contraception and Chemotherapy for trypanosomiasis and Leshmaniasis: An Analysis of Biochemical Similarities and Considerations for Future Research. In Cellular and Molecular Events in Spermiogenesis pp. 285-308. Edited by D. Hamilton, and G.M.H. Waites. London: Cambridge University Press.
  • Docampo, R. (1990) Sensitivity of parasites to free radical damage by antiparasitic drugs. Chem.-Biol. Interact. 73, 1-27.
  • Vercesi, A.E., Macedo, D.V., Lima, S.A., Gadelha, F.R., and Docampo, R. (1990) Ca2+ transport in digitonin-permeabilized trypanosomatids. Mol. Biochem. Parasitol. 42, 119-124.
  • Gadelha, F.R., Moreno, S.N.J., de Souza, W., Cruz, F.S, and Docampo, R. (1989) The mitochondrion of Trypanosoma cruzi is a target of crystal violet toxicity. Mol. Biochem. Parasitol. 34, 117-126.
  • Moreno, S.N.J. and Docampo, R. (1989) Reduction of 5-Nitroimidazoles, Nitrofurazone, and 2,4-Dinitrophenol to their Free Radical Metabolites by Tritrichomonas foetus hydrogenosomes.. In Oxygen Radicals in Biology and Medicine, pp. 759-764. Edited by M.G. Simic, K.A. Taylor, J.F. Ward, and C. von Sonntag. New York, Plenum Publishing Corporation.
  • Docampo, R., and Vercesi, A.E. (1989) Ca2+ transport by coupled Trypanosoma cruzi mitochondria in situ. J. Biol. Chem. 264, 108-111.
  • Docampo, R., and Vercesi, A.E. (1989) Characteristics of Ca2+ transport by Trypanosoma cruzi mitochondria in situ. Arch. Biochem. Biophys. 272, 122-129.
  • Docampo, R., Moreno, S.N.J., and Cruz, F.S. (1988) Enhancement of the cytotoxicity of crystal violet against Trypanosoma cruzi in the blood by ascorbate.. Mol. Biochem. Parasitol. 27, 241-248.
  • Docampo, R., Moreno, S.N.J., and Mason, R.P. (1988) Generation of superoxide anion and hydrogen peroxide during redox cycling of 5(-4-nitrophenyl)penta-2,4-dienal (NPPD) by mammalian microsomes and enzymes. Chem.-Biol. Interact. 65, 123-131.
  • Moreno, S.N.J., Gadelha, F.R., and Docampo, R. (1988) Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria. J. Biol. Chem. 263, 12493-12499.
  • Docampo, R., Moreno, S.N.J., Gadelha, F.R., de Souza, W., and Cruz, F.S. (1988) Prevention of Chagas'disease resulting from blood transfusion by treatment of blood: toxicity and mode of action of gentian violet. Biomed. Environm. Sci. 1, 406-413.
  • Docampo, R., Moreno, S.N.J. and Mason, R.P. (1987) Free radical intermediates in the reaction of pyruvate:ferredoxin oxidoreductase in Tritrichomonas foetus hydrogenosomes. J. Biol. Chem. 262, 12417-12420.
  • Albonico, S.M., Assem, M.E., Benages, A.A., Montiel, A.A., Pizzorno, M.T., Docampo, R., and Stoppani, A.O.M. (1987) Synthetic trypanocides: growth-inhibiting properties of new 1,2,3,4-tetrahydrocarbazoles on Trypanosoma cruzi. Rev. Asoc. Arg. Microbiol. 19, 121-124.
  • Docampo, R. and Moreno, S.N.J. (1986) Free radical metabolism of antiparasitic agents. Fed. Proceed. 45, 2471-2476.
  • Marr, J.J., and Docampo, R. (1986) Chemotherapy of Chagas' disease. A perspective of current therapy and considerations for future research. Rev. Infect. Dis. 8, 884-903.
  • Reszka, K., Cruz, F.S., and Docampo, R. (1986) Photosensitization by the trypanocidal agent gentian violet. Type I versus Type II reactions. Chem.-Biol. Interact. 58, 161-172.
  • Moreno, S.N.J. and Docampo, R. (1985) The mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis. Environm. Hlth Perspect. 64, 199-208.
    Moreno, S.N.J., Mason, R.P., and Docampo, R. (1985) Reduction of the metallochromic indicators arsenazo III and antipyrylazo III to their free radical metabolites by cytoplasmic enzymes. FEBS Lett. 180, 229-233.
  • Moreno, S.N.J. and Docampo, R. (1985) Reduction of the metallochromic indicators murexide and tetramethylmurexide to their free radical metabolites by cytoplasmic enzymes and reducing agents. Chem.-Biol. Interact. 57, 17-25.
  • Docampo, R. and Moreno, S.N.J. (1985) Biochemical Toxicology of Antiparasitic Drugs Used in the Chemotherapy and Chemoprophylaxis of American Trypanosomiasis (Chagas' Disease). In Reviews in Biochemical Toxicology, Vol. VII, pp. 159-204. Edited by E. Hodgson, J.R. Bend, and R.M. Philpot. New York, Elsevier Biomedical.
  • Cardoni, R.L., de Titto, E.H., and Docampo, R. (1985) On the mechanism of killing of Trypanosoma cruzi by human polymorphonuclear leukocytes. Experientia 41, 89-91.
  • Docampo, R. and Moreno, S.N.J. (1984) Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi.. Rev. Infect. Dis. 6, 223-238.
  • Moreno, S.N.J., Mason, R.P., and Docampo, R. (1984) Reduction of nifurtimox and nitrofurantoin by intact rat liver mitochondria. Evidence of an outer membrane-located nitroreductase. J. Biol. Chem. 259, 6298-6305.
  • Moreno, S.N.J., Mason, R.P., and Docampo, R. (1984) Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes. J. Biol. Chem.. 259, 8252-8259.
  • Cruz, F.S., Lopes, L.A.V., De Souza, W., Moreno, S.N.J., Mason, R.P., and. Docampo, R. (1984) The photodynamic action of rose bengal on Trypanosoma cruzi. Acta Trop. 41, 99-108.
  • Moreno, S.N.J., Mason, R.P., and Docampo, R. (1984) Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase. J. Biol. Chem. 259, 14609-14616.
  • Docampo, R. and Moreno, S.N.J. (1984) Free Radical Intermediates in the Antiparasitic Action of Drugs and Phagocytic Cells. In Free Radicals in Biology, Vol. 6, pp. 243-288. Edited by W.A. Pryor. New York, Academic Press.
  • Docampo, R., and Moreno, S.N.J.  (1984) Free Radical Intermediates in the Trypanocidal Action of Drugs and Phagocytic Cells.. In Oxygen Radicals in Chemistry and Biology, pp. 749-752. Edited by W. Bors, M. Saran, and D. Tait. Berlin, Walter de Gruyter.
  • Docampo, R., Dubin, M., Martino E.E., Moreno, S.N.J. and Stoppani, A.O.M. (1983) Effect of nifurtimox on glutathione content in liver and bile in the rat. Medicina (Buenos Aires) 43, 33-40.
    Moreno, S.N.J., Docampo, R., and Stoppani, A.O.M. (1983) About undesirable effects of nifurtimox and benznidazole. Medicina (Buenos Aires) 43, 291-296.
  • Docampo, R., Casellas, A.M., Madeira, E.D., Cardoni, R.L., Moreno, S.N.J., and Mason, R.P. (1983) Oxygen-derived radicals from Trypanosoma cruzi-stimulated human neutrophils. FEBS Lett. 155, 25-30.
  • Moreno, S.N.J., Mason, R.P., Muniz, R.P.A., Cruz, F.S., and Docampo, R. (1983) Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus. J. Biol. Chem. 258, 4051-4054.
  • Docampo, R., Moreno, S.N.J., Muniz, R.P.A., Cruz, F.S., and Mason, R.P. (1983) Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Science  220, 1292-1295.
  • Docampo, R., Moreno, S.N.J. and Mason, R.P. (1983) Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes. J. Biol. Chem. 258, 14920-14925.
  • Moreno, S.N.J., Docampo, R., Mason, R.P., Leon, W. and Stoppani, A.O.M. (1982) Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi  microsomal preparations. Arch. Biochem. Biophys. 218, 585-591.
  • Dubin, M., Moreno, S.N.J., Martino, E.E., Docampo, R., and Stoppani, A.O.M. (1982) Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment. Biochem. Pharmacol. 32, 483-487.
  • Docampo, R. , Cardoni,R.L.,  Casellas, A.M. and  De Souza, W. (1982) Antibody-dependent Cytolysis of Trypanosoma cruzi by Polymorphonuclear Leukocytes:       Dependence on the Respiratory burst.  In Nuclear Techniques in the Study of Parasitic Infections, pp. 61-71. Vienna; International Atomic Energy Agency.
  • Cannata, J.J.B., Valle, E., Docampo, R., and Cazzulo, J.J. (1982) Subcellular localization of phosphoenolpyruvate carboxykinase in the trypanosomatids Trypanosoma cruzi and Crithidia fasciculata. Mol. Biochem. Parasitol. 6, 151-160.
  • Salzman, T.A., Stella, A.M., Wider de Xifra, E., del Batlle, C.A.M.C., Docampo, R., and Stoppani, A.O.M. (1982) Porphyrin biosynthesis in parasitic hemoflagellates: functional and defective enzymes in Trypanosoma cruzi. Comp. Biochem. Physiol. B72, 663-667.
  • Cardoni, R.L., Docampo, R., and Casellas, A.M. (1982) Metabolic requirements for the damage of Trypanosoma cruzi epimastigotes by human polymorphonuclear leukocytes. J. Parasitol. 68, 547-552.
  • Docampo, R., Moreno, S.N.J., Stoppani, A.O.M., Cruz, F.S., Leon, W., Villalta, F., and Muniz, R.P.A. (1981) Mechanism of nifurtimox toxicity in different stages of Trypanosoma cruzi. Biochem. Pharmacol. 30, 1947-1951.
  • Docampo, R., Moreno, S.N.J., Turrens, J.F., Katzin, A.M., Gonzalez-Cappa, S.M., and Stoppani, A.O.M. (1981) Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi. Mol. Biochem. Parasitol. 3, 169-180.
  • Docampo, R., Moreno, S.N.J., and Stoppani, A.O.M. (1981) Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation. Arch. Biochem. Biophys. 207, 316-322.
  • Stoppani, A.O.M., Docampo, R., and Moreno, S.N.J. (1981) Biochemical basis of Chagas' disease chemotherapy. Rev. Asoc. Med. Arg. 175-180, Set-Dec.
  • Docampo, R., Mason, R.P., Mottley, C., and Muniz, R.P.A. (1981) Generation of free radicals induced by nifurtimox in mammalian tissues. J. Biol. Chem. 256, 10930-10933.
  • Moreno, S.N.J., Palmero, D.J., de Palmero K.E., Docampo, R., and A.O.M. Stoppani (1980) Stimulation of lipid peroxidation and ultrastructural alterations induced by nifurtimox in mammalian tissues. Medicina (Buenos Aires) 40, 563-559.
  • Boiso, J.F. de, Docampo, R., and Stoppani, A.O.M. (1980) Antimycin inhibition of respiration and growth of Trypanosoma cruzi. Medicina (Buenos Aires) 39, 362-368.
  • Docampo, R., and Stoppani, A.O.M. (1980) Generation of oxygen reduction derivatives induced by nifurtimox and other nitrocompounds in Trypanosoma cruzi. Medicina (Buenos Aires) 40, 10-16.
  • Docampo, R. (1980) Generation of Free Radicals from Nifurtimox in Trypanosoma cruzi and in the mammalian host. In The Host Invader Interplay, pp. 677-681. Edited by H.Van den Bossche, Amsterdam: Elsevier-North Holland.
  • Cannata, J.J.B., Docampo, R., Valle, E., Franke de Cazzulo, and Cazzulo, J.J. (1980) Intracellular distribution of CO2-fixing enzymes in Trypanosoma cruzi and Crithidia fasciculata. Medicina (Buenos Aires) 40, 145-153.
  • Docampo, R. (1980) Generation of free radicals induced by nifurtimox in mammalian tissues. Rev. Soc. Arg. Biol. 56, 15-27.
  • Boveris, A., Sies, H., Martino, E.E., Docampo, R., Turrens, J.F., and Stoppani, A.O.M. (1980) Deficient metabolic utilization of H202 in Trypanosoma cruzi. Biochem. J. 188, 643-648.
  • Goncalves, A.M., Vasconcellos, M.E.L., Docampo, R., Cruz, F.S., De Souza, W., and Leon, W. (1980) Evaluation of the toxicity of 3-allyl-b-lapachone against Trypanosoma cruzi bloodstream forms. Mol. Biochem. Parasitol. 1, 167-176.
  • Cazzulo, J.J., Valle, E., Docampo, R., and Cannata, J.J.B. (1980) Intracellular distribution of CO2 fixing enzymes in Trypanosoma cruzi and Crithidia fasciculata. J. Gen. Microbiol. 117, 271-274.
  • Stoppani, A.O.M., Docampo, R., Boiso, J.F. de, and Frasch, A.C.C. (1980) Effect of inhibitors of electron transport and oxidative phsophorylation on Trypanosoma cruzi respiration and growth. Mol. Biochem. Parasitol. 2, 3-21.
  • Docampo, R., Cruz, F.S., Leon, W., and Schmunis, G.A. (1979) Acetate oxidation by bloodstream forms of Trypanosoma cruzi. J. Protozool. 26, 301-303.
  • Docampo, R., Cruz, F.S., Boveris, A., Muniz, R.P.A., and Esquivel, D.M.S. (1979) b-Lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by sarcoma 180 ascitis tumor cells. Biochem. Pharmacol. 28, 723-729.
  • De Souza, W., Souto-Padron, T., Docampo, R., Chaves, L., and Leon, W. (1979) The presence of basic proteins associated to the kinetoplast DNA of Trypanosoma cruzi epimastigotes. Acta Trop. 36, 253-255.
  • Docampo, R., and Stoppani, A.O.M. (1979) Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch. Biochem. Biophys. 197, 317-321.
  • Boiso, J.F. de, Docampo, R., and Stoppani, A.O.M. (1979) Cytochromes in culture forms of Trypanosoma cruzi. Rev. Asoc. Arg. Microbiol. 11, 22-36.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1978) Tricarboxylic acid cycle operation at the kinetoplast-mitochondrion  complex of Trypanosoma cruzi. Biochim. Biophys. Acta 502, 466-476.
  • Cruz, F.S., Docampo, R., and De Souza, W. (1978) Effect of b-lapachone on hydrogen peroxide production in Trypanosoma cruzi.  Acta Trop. 35, 35-40.
  • Docampo, R., Cruz, F.S., Boveris, A., Muniz, R.P.A., and Esquivel, D.M.S. (1978) Lipid peroxidation and the generation of free radicals, superoxide anion and hydrogen peroxide in b-lapachone-treated Trypanosoma cruzi epimastigotes. Arch. Biochem. Biophys. 186, 292-297.
  • Lopes, J.N., Cruz, F.S., Docampo, R., Vasconcellos, M.E.L., Sampaio, M.C.R., Pinto, A.V., and Gilbert, B. (1978)  "In vitro" and "in vivo" evaluation of the toxicity of 1,4-naphthoquinones and 1,2-naphthoquinone derivatives against Trypanosoma cruzi. Ann. Trop. Med. Parasitol. 72, 521-531.
  • Docampo, R., Cruz, F.S., Muniz, R.P.A., Esquivel, D.M.S., and Vasconcellos, M.E.L. (1978) Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes. Acta Trop. 35, 221-228.
  • Leon, L., Vasconcellos, M.E.L., Leon, W., Cruz, F.S., Docampo, R., and De Souza, W. (1978) Trypanosoma cruzi: Effect of olivacine on macromolecular synthesis, ultrastructure and respiration of epimastigotes. Exp. Parasitol. 45, 151-159.
  • Boveris, A., Docampo, R., Turrens, J.F., and Stoppani, A.O.M. (1978) Effect of b-lapachone and a-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi. Biochem. J. 175, 431-439.
  • Boveris, A., Stoppani, A.O.M., Docampo, R., and Cruz, F.S. (1978) Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi. Comp. Biochem. Physiol. C61, 327-329.
  • Cruz, F.S., Docampo, R., and Boveris, A. (1978) Effect of b-lapachone on peroxide production in bacteria. Antimicrob. Agents Chemother. 14, 630-633.
  • Docampo, R., De Souza, W., Cruz, F.S., Roitman, I., Cover, B., and Gutteridge, W. (1978) Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages of Trypanosoma cruzi. Z. Parasitenkd. (Parasitol. Res.) 57, 189-198.
  • Boiso, J.F. de, Docampo, R., and Stoppani, A.O.M. (1977) Histochemical investigation of microperoxisomes in Trypanosoma cruzi. Medicina (Buenos Aires) 37, 365-370.
  • Boveris, A., Docampo, R., Turrens, J.F., and Stoppani, A.O.M. (1977) Effect of a- and b-lapachone on H202 production and growth of Trypanosoma cruzi. Rev. Asoc. Arg. Microbiol. 9, 54-61.
  • Docampo, R., Lopes, J.N., Cruz, F.S., and De Souza, W. (1977) Trypanosoma cruzi: Ultrastructural and metabolic alterations of epimastigotes by b-lapachone. Exp. Parasitol. 42, 142-149.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1976) Glyceraldehyde-3-phosphate dehydrogenase activity in soluble extracts of the epimastigote form of Trypanosoma cruzi.  Rev. Asoc. Arg. Microbiol. 8, 21-25.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1976) Identification of microperoxisomes in Trypanosoma cruzi. Rev. Soc. Arg. Biol. 52, 44-49.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1976) Localization of peroxidase activity in Trypanosoma cruzi microbodies.  Experientia 32, 365-370.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1974) Metabolic alterations in diskinetoplastic Trypanosoma cruzi.  Medicina (Buenos Aires) 34, 525-531.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1974) Scanning and transmission electron microscopy studies of Trypanosoma cruzi. Rev. Soc. Arg. Biol. 50, 93-100.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1974) Metabolic differences in Trypanosoma cruzi cultivated in different media. Rev. Asoc. Arg. Microbiol. 6, 7-14.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1974) New observations on the ultrastructure of Trypanosoma cruzi by scanning and transmission electron microscopy.  Rev. Asoc. Arg. Microbiol. 6, 119-126.
  • Docampo, R., Boiso, J.F. de, and Stoppani, A.O.M. (1973) Trypanosoma cruzi growth in diphasic and liquid medium. Effect of ethidium bromide. Rev. Asoc. Arg. Microbiol. 5, 117-122